import React, { Component } from 'react'
import {
  Card,
  Tooltip,
  Popover,
  message,
  Radio,
  Button,
  Tabs,
  Spin,
  Table,
  Tag,
  Input,
  Collapse,
  Modal,
  Form,
  Select,
  InputNumber,
  Typography,
  Icon,
  Anchor,
  Pagination,
} from 'antd'
import WrappedIframe from '../../../components/iframePdb'
import { request } from '../../../utils/request'
import Molstar from 'molstar-react'
import { Jsme } from 'jsme-react'
import qs from 'qs'
import './index.css'
const { Panel } = Collapse
const { TabPane } = Tabs
const { Option } = Select
const { Title } = Typography
const { Link } = Anchor
let id = 0
@Form.create()
export default class TargetDetails extends Component {
  state = {
    name: '',
    Structure: [],
    dataOne: qs.parse(this.props.location.search.slice(1)),
    visible: false,
    visible2: false,
    pdbId: '6f6s',
    DetailsData: {
      PubChemCID: 5462310,
      MolecularWeight: 12.011,
      smiles: 'cccc',
    },
    panelList: {
      Bioassay: [],
    },
    statusMutation: 0,
    OLDMutationList: [],

    targetsDetail: {
      Structure: [],
      Sequence: [],
      MutationList: [],
      Bioassay: [],
      DrugsInformation: [],
      Gene_name: []
    },
    loading: true,
    getStructureList: {
      ligand_up_list: [],
      ligand_list: [],
      chain: [],
      References: [],
    },
    listData: {
      pdb_code: '',
      ligand: '',
      resolution: 0,
    },
    fileData: {
      filestring: '',
      type: 'pdb',
    },
    SequenceAlignment: {
      reference: '',
      aligns: '',
    },
    SequenceAlignmentList: [],
    MutationSearch: {
      page: 1,
      page_size: 10,
      dataid: qs.parse(this.props.location.search.slice(1)).dataid,
      status: 0,
      desc: 1,
    },
    BioassaySearch: {
      page: 1,
      page_size: 10,
      dataid: qs.parse(this.props.location.search.slice(1)).dataid,
      drugs_data: "",
      finger: 0
    },
    DrugClinicalImformationSearch: {
      page: 1,
      page_size: 10,
      dataid: qs.parse(this.props.location.search.slice(1)).dataid,
    },
    VirantsDiseaseListSearch: {
      page: 1,
      page_size: 10,
      dataid: qs.parse(this.props.location.search.slice(1)).dataid,
    },
    VirantsDiseaseList: [],
    total_num: 0,
    total_num2: 0,
    total_num3: 0,
    total_num4: 0,
    total_num5: 0,
    pdbLink: '',
    pdbLink2: '',
    addList: ['super', 'align'],
    sum: 0,
    superpositionData: [
      {
        chainID: '',
        pdbID: '',
      },
      {
        chainID: '',
        pdbID: '',
        method: '',
        cutoff: 0,
        cycles: 0,
      },
      {
        chainID: '',
        pdbID: '',
        method: '',
        cutoff: 0,
        cycles: 0,
      },
    ],
    aciveKey: '',
    directoryState: false,
    visible3: false
  }
  componentDidMount () {
    this.getDetails()
  }
  getDetails () {
    // this.setState({loading:true})
    this.setState({ loading: true })
    request
      .post(
        'kinase/target_detail',
        qs.parse(this.props.location.search.slice(1))
      )
      .then((res) => {
        this.setState({ loading: false })
        if (res.data.code === 200) {
          console.log(res)

          let data = res.data.data
          this.setState({ targetsDetail: data })
          this.setState({ OLDMutationList: data.Mutation })

          this.setState({ loading: false })
          let StructureList = res.data.data.Structure
          if (StructureList.length > 0) {
            this.getStructure(StructureList[0].pdb)
            this.setState({
              aciveKey: StructureList[0].pdb,
            })
          }
          this.DrugClinicalImformationList()
          // this.getMutationList()
          this.getBioassayList()
          this.getVirantsDiseaseList()
        } else {
          message.error(res.data.msg)
        }
      })
      .catch((err) => {
        console.error(err)
      })
  }
  getMutationList = () => {
    console.log(this.state.dataOne)
    const { dataid } = this.state.dataOne
    this.setState({ loading: true })
    request
      .post('kinase/target_detail/mutation', this.state.MutationSearch)
      .then((res) => {
        this.setState({ loading: false })
        if (res) {
          let targetsDetail = this.state.targetsDetail
          targetsDetail.MutationList = res.data.data
          this.setState({ total_num: res.data.total_num })
          this.setState({
            targetsDetail,
          })
        }
      })
      .catch((err) => {
        console.error(err)
      })
  }
  onChangeTable = (pagination, filters, sorter, extra) => {
    // console.log('params', pagination, filters, sorter, extra)
    console.log(sorter)
    if (sorter.order === 'ascend') {
      let MutationSearch = this.state.MutationSearch
      MutationSearch.desc = 1
      this.setState(() => ({ MutationSearch: MutationSearch }))
      this.getMutationList()
    }
    if (sorter.order === 'descend') {
      let MutationSearch = this.state.MutationSearch
      MutationSearch.desc = 2
      this.setState(() => ({ MutationSearch: MutationSearch }))
      this.getMutationList()
    }
  }
  onShowSizeChange = (current, pageSize) => {
    console.log(current, pageSize)
    let MutationSearch = this.state.MutationSearch
    MutationSearch.page = current
    MutationSearch.page_size = pageSize
    this.setState({
      MutationSearch,
    })
    this.getMutationList()
  }
  onChange = (current, pageSize) => {
    console.log(current, pageSize)
    let MutationSearch = this.state.MutationSearch
    MutationSearch.page = current
    MutationSearch.page_size = pageSize
    this.setState({
      MutationSearch,
    })
    this.getMutationList()
  }
  getBioassayList = () => {
    console.log(this.state.dataOne)
    const { dataid } = this.state.dataOne
    this.setState({ loading: true })
    request
      .post('kinase/target_detail/bioassay', this.state.BioassaySearch)
      .then((res) => {
        this.setState({ loading: false })
        if (res) {
          console.log(res)
          let targetsDetail = this.state.targetsDetail
          targetsDetail.Bioassay = res.data.data
          this.setState({ total_num2: res.data.total_num })
          this.setState({
            targetsDetail: targetsDetail,
          })
          this.setState({ visible3: false })
        }
      })
      .catch((err) => {
        console.error(err)
      })
  }
  getVirantsDiseaseList = () => {
    console.log(this.state.dataOne)
    this.setState({ loading: true })
    console.log(this.state.VirantsDiseaseListSearch)
    request
      .post(
        'kinase/target_detail/virants_disease',
        this.state.VirantsDiseaseListSearch
      )
      .then((res) => {
        this.setState({ loading: false })
        if (res) {
          console.log(res)
          // let DetailsData = this.state.DetailsData
          // DetailsData.Target = res.data.data
          this.setState({ total_num5: res.data.total_num })
          this.setState({
            VirantsDiseaseList: res.data.data,
          })
        }
      })
      .catch((err) => {
        console.error(err)
      })
  }
  onShowSizeChange5 = (current, pageSize) => {
    console.log(current, pageSize)
    let VirantsDiseaseListSearch = this.state.VirantsDiseaseListSearch
    VirantsDiseaseListSearch.page = current
    VirantsDiseaseListSearch.page_size = pageSize
    this.setState({
      VirantsDiseaseListSearch,
    })
    this.getVirantsDiseaseList()
  }
  onChange5 = (current, pageSize) => {
    console.log(current, pageSize)
    let VirantsDiseaseListSearch = this.state.VirantsDiseaseListSearch
    VirantsDiseaseListSearch.page = current
    VirantsDiseaseListSearch.page_size = pageSize
    this.setState({
      VirantsDiseaseListSearch,
    })
    this.getVirantsDiseaseList()
  }
  onShowSizeChange2 = (current, pageSize) => {
    let BioassaySearch = this.state.BioassaySearch
    BioassaySearch.page = current
    BioassaySearch.page_size = pageSize
    this.setState({
      BioassaySearch,
    })
    this.getBioassayList()
  }
  onChange2 = (current, pageSize) => {
    let BioassaySearch = this.state.BioassaySearch
    BioassaySearch.page = current
    BioassaySearch.page_size = pageSize
    this.setState({
      BioassaySearch,
    })

    this.getBioassayList()
  }
  DrugClinicalImformationList = () => {
    console.log(this.state.dataOne)
    const { dataid } = this.state.dataOne
    this.setState({ loading: true })
    request
      .post(
        'kinase/target_detail/drug_information',
        this.state.DrugClinicalImformationSearch
      )
      .then((res) => {
        this.setState({ loading: false })
        if (res) {
          console.log(res)
          let targetsDetail = this.state.targetsDetail
          targetsDetail.DrugsInformation = res.data.data
          this.setState({ total_num3: res.data.total_num })
          this.setState({
            targetsDetail: targetsDetail,
          })
        }
      })
      .catch((err) => {
        console.error(err)
      })
  }
  onShowSizeChange3 = (current, pageSize) => {
    let DrugClinicalImformationSearch = this.state.DrugClinicalImformationSearch
    DrugClinicalImformationSearch.page = current
    DrugClinicalImformationSearch.page_size = pageSize
    this.setState({
      DrugClinicalImformationSearch,
    })
    this.DrugClinicalImformationList()
  }
  onChange3 = (current, pageSize) => {
    let DrugClinicalImformationSearch = this.state.DrugClinicalImformationSearch
    DrugClinicalImformationSearch.page = current
    DrugClinicalImformationSearch.page_size = pageSize
    this.setState({
      DrugClinicalImformationSearch,
    })

    this.DrugClinicalImformationList()
  }
  getPdid (e) {
    console.log(e)
    this.setState({ visible: true })
    this.setState({ pdbId: e })
  }
  getTag = (e) => {
    console.log(e)
    this.setState({ visible: true })
    this.setState({ pdbId: e })
  }
  getReferences = (e) => {
    window.open(`https://pubmed.ncbi.nlm.nih.gov/${e}`)
  }
  getReferences2 = (e) => {
    console.log(e)
    window.open(e)
  }
  onChangeRadio = (e) => {
    let value = e.target.value
    let MutationSearch = this.state.MutationSearch
    MutationSearch.status = value
    this.setState(() => ({ MutationSearch: MutationSearch }))
    this.getMutationList()
  }
  getDrug = (e) => {
    console.log(e)
    let data = {
      dataid: e,
    }
    this.props.history.push({
      pathname: '/kinase/SearchDetails',
      search: qs.stringify(data),
    })
  }

  callback () { }
  childTargetClassChange = () => { }
  getStructure = (e) => {
    request
      .post(
        '/search_pdb_data',
        qs.stringify({
          pdb: e,
        })
      )
      .then((res) => {
        this.setState({ loading: false })
        if (res.data.code === 200) {
          this.setState({ getStructureList: res.data.data })
          let listData = this.state.listData
          listData.pdb_code = res.data.data.name
          listData.ligand = ''
          listData.resolution = 0
          this.setState({ listData })

          let pdbLink =
            'http://52.83.169.190:3004/?id=' + JSON.stringify(listData)
          this.setState({
            pdbLink,
          })
        } else {
          message.error(res.data.msg)
        }
      })
      .catch((err) => {
        console.error(err)
      })
  }
  ChangeTabs = (e) => {
    this.setState({
      aciveKey: e,
    })
    this.setState({
      pdbLink: '',
    })
    let listData = this.state.listData
    listData.ligand = ''
    listData.resolution = 0
    if (listData.pdbList) {
      delete listData.pdbList
    }
    this.setState({
      listData: listData,
      pdbLink: '',
    })
    this.getStructure(e)
  }
  getList = () => {
    console.log('getList')
    if (this.state.listData.ligand === '') {
      message.warning('输入查询条件')
      return
    }
    JSON.stringify(this.state.listData)
    let listData = this.state.listData
    listData.pdbList = this.state.pdbList
    let pdbLink = 'http://52.83.169.190:3004/?id=' + JSON.stringify(listData)
    this.setState({
      pdbLink,
    })
  }

  getResolutionData = (e) => {
    console.log(e)
    let listData = this.state.listData
    listData.resolution = e
    this.setState({
      listData,
    })
  }
  LigandChange = (e) => {
    let listData = this.state.listData
    listData.ligand = e
    this.setState({
      listData,
    })
  }
  sequenceAlign = () => {
    request
      .post('kinase/sequence_align', qs.stringify(this.state.SequenceAlignment))
      .then((res) => {
        console.log(res)
        this.setState({ loading: false })
        if (res.data.code === 200) {
          this.setState({ SequenceAlignmentList: res.data.data })
        } else {
          message.error(res.data.msg)
        }
      })
      .catch((err) => {
        console.error(err)
      })
  }
  remove = (k) => {
    const { form } = this.props
    // can use data-binding to get
    const keys = form.getFieldValue('keys')
    // We need at least one passenger
    if (keys.length === 1) {
      return
    }

    // can use data-binding to set
    form.setFieldsValue({
      keys: keys.filter((key) => key !== k),
    })
  }

  add = () => {
    const { form } = this.props
    // can use data-binding to get
    const keys = form.getFieldValue('keys')
    const nextKeys = keys.concat(id++)
    // can use data-binding to set
    // important! notify form to detect changes
    form.setFieldsValue({
      keys: nextKeys,
    })
  }

  handleSubmit = (e) => {
    console.log(e)
    e.preventDefault()
    this.props.form.validateFields((err, values) => {
      const { keys, names } = values
      // console.log('Received values of form: ', values);
      // console.log('Merged values:', keys.map(key => names[key]));
      // let names=keys.map(key => names[key])
      console.log(names)

      for (let index = 0; index < names.length; index++) {
        var element = names[index]
        if (element == undefined) {
          names[index] = ''
        }
      }
      let newArr = names.filter((i) => i && i.trim())
      console.log(newArr)

      let SequenceAlignment = this.state.SequenceAlignment
      SequenceAlignment.aligns = newArr.toString()
      SequenceAlignment.reference = this.state.targetsDetail.name
      this.setState(() => ({ SequenceAlignment: SequenceAlignment }))

      this.sequenceAlign()
    })
  }
  getSequence = (e) => {
    const { value } = e.target
    let SequenceAlignment = this.state.SequenceAlignment
    SequenceAlignment.reference = value
    this.setState(() => ({ SequenceAlignment: SequenceAlignment }))
  }
  handleAnchorClick = (e) => {
    e.preventDefault()
  }
  getValue = (e) => {
    const { value } = e.target
    let superpositionData = this.state.superpositionData
    superpositionData[0].chainID = value
    this.setState(() => ({ superpositionData: superpositionData }))
  }
  SelectValue = (e) => {
    console.log(e)
    let superpositionData = this.state.superpositionData
    superpositionData[0].pdbID = e
    this.setState(() => ({ superpositionData: superpositionData }))
  }
  onChangeGroup = (e) => {
    console.log(e)
    this.setState({
      pdbList: e,
    })
  }
  remove2 = (k) => {
    const { form } = this.props
    // can use data-binding to get
    const keys2 = form.getFieldValue('keys')
    // We need at least one passenger
    if (keys2.length === 1) {
      return
    }

    this.setState({
      sum: keys2.length - 1,
    })

    // can use data-binding to set
    form.setFieldsValue({
      keys2: keys2.filter((key) => key !== k),
    })
  }

  add2 = () => {
    const { form } = this.props
    // can use data-binding to get
    const keys2 = form.getFieldValue('keys')
    const nextKeys = keys2.concat(id++)
    // can use data-binding to set
    // important! notify form to detect changes
    form.setFieldsValue({
      keys: nextKeys,
    })
    this.setState({
      sum: keys2.length + 1,
    })
  }

  handleSubmit2 = (e) => {
    // console.log(e);
    // e.preventDefault();
    this.props.form.validateFields((err, values) => {
      console.log(values)
      const {
        keys,
        pdbList,
        chainList,
        methodList,
        cutoffList,
        cyclesList,
      } = values
      console.log('Received values of form: ', values)
      // console.log('Merged values:', keys.map(key => names[key]))
      // let names = keys.map(key => names[key])

      for (let index = 0; index < pdbList.length; index++) {
        var element = pdbList[index]
        if (element == undefined) {
          pdbList[index] = ''
        }
      }
      let newArr = pdbList.filter((i) => i && i.trim())
      for (let index = 0; index < chainList.length; index++) {
        var element = chainList[index]
        if (element == undefined) {
          chainList[index] = ''
        }
      }
      let newArr2 = chainList.filter((i) => i && i.trim())
      for (let index = 0; index < methodList.length; index++) {
        var element = methodList[index]
        if (element == undefined) {
          methodList[index] = ''
        }
      }
      let newArr3 = methodList.filter((i) => i && i.trim())
      for (let index = 0; index < cutoffList.length; index++) {
        var element = cutoffList[index]
        if (element == undefined) {
          cutoffList[index] = ''
        }
      }
      let newArr4 = cutoffList.filter((i) => i && i.trim())
      for (let index = 0; index < cyclesList.length; index++) {
        var element = cyclesList[index]
        if (element == undefined) {
          cyclesList[index] = ''
        }
      }
      let newArr5 = cyclesList.filter((i) => i && i.trim())
      console.log(newArr2)
      let superpositionData = this.state.superpositionData
      superpositionData[1].pdbID = newArr[0] === undefined ? '' : newArr[0]
      superpositionData[1].chainID = newArr2[0] === undefined ? '' : newArr2[0]
      superpositionData[1].method = newArr3[0] === undefined ? '' : newArr3[0]
      superpositionData[1].cutoff =
        newArr4[0] === undefined ? '' : parseInt(newArr4[0])
      superpositionData[1].cycles =
        newArr5[0] === undefined ? '' : parseInt(newArr5[0])
      superpositionData[2].pdbID = newArr[1] === undefined ? '' : newArr[1]
      superpositionData[2].chainID = newArr2[1] === undefined ? '' : newArr2[1]
      superpositionData[2].method = newArr3[1] === undefined ? '' : newArr3[1]
        ; (superpositionData[2].cutoff =
          newArr4[1] === undefined ? '' : parseInt(newArr4[1])),
          (superpositionData[2].cycles =
            newArr5[1] === undefined ? '' : parseInt(newArr5[1]))
      this.setState(() => ({ superpositionData: superpositionData }))
      console.log(this.state.superpositionData)
      let listData = this.state.listData
      listData.pdbList = this.state.superpositionData
      let pdbLink = 'http://52.83.169.190:3004/?id=' + JSON.stringify(listData)
      this.setState({ listData })
      this.setState({ pdbLink })
      console.log(this.state.pdbLink)
    })
  }
  alignmentEve = () => {
    this.setState({ visible2: true })
    this.props.form.resetFields()
  }
  onCancelForm = () => {
    this.setState({ visible2: false })
    this.props.form.resetFields()
  }
  logSmiles2 = (e) => {
    let BioassaySearch = this.state.BioassaySearch
    BioassaySearch.drugs_data = e
    this.setState(() => ({ BioassaySearch: BioassaySearch }))
    // this.setState(()=>({data:e }))
  }
  getLigendValue = (e) => {
    const { value } = e.target
    let BioassaySearch = this.state.BioassaySearch
    BioassaySearch.drugs_data = value
    this.setState(() => ({ BioassaySearch: BioassaySearch }))
  }
  onChangeRadio4 = (e) => {
    let value = e.target.value
    let BioassaySearch = this.state.BioassaySearch
    BioassaySearch.finger = value
    this.setState({
      BioassaySearch: BioassaySearch,
    })
  }

  render () {
    const {
      visible,
      visible2,
      SequenceAlignmentList,
      OLDMutationList,
      targetsDetail,
      getStructureList,
      total_num,
      total_num2,
      total_num3,
      total_num5,
      VirantsDiseaseList,
      sum,
      addList,
      directoryState,
      visible3
    } = this.state
    const { getFieldDecorator, getFieldValue } = this.props.form
    const columnsVirantsDisease = [
      {
        title: 'Consequence Type',
        dataIndex: 'Consequence Type',
        key: 'Consequence Type',
      },
      {
        title: 'Gene Position',
        dataIndex: 'Gene Position',
        key: 'Gene Position',
      },
      {
        title: 'Protein Position',
        dataIndex: 'Protein Position',
        key: 'Protein Position',
      },
    ]
    const expandedRowRender = (e) => {
      console.log(e)
      const { Conditions } = e
      const columns = [

        {
          title: 'indication',
          dataIndex: 'indication',
          key: 'indication',
        },
        {
          title: 'phase',
          dataIndex: 'phase',
          key: 'phase',
        },
        {
          title: 'purpose',
          dataIndex: 'purpose',
          key: 'purpose',
        },
        {
          title: 'status',
          dataIndex: 'status',
          key: 'status',
        },
        {
          title: 'reference',
          dataIndex: 'reference',
          key: 'reference',
          render: (reference) => (
            <span>
              {
                <Tag
                  color="blue"
                  onClick={() => {
                    this.getReferences2(reference)
                  }}>
                  <a href={reference} />
                  {reference}
                </Tag>
              }
            </span>
          ),
        },
      ]
      return (
        <Table
          columns={columns}
          rowKey="item"
          dataSource={Conditions}
          pagination={false}
        />
      )
    }
    const expandedRowRender2 = (e) => {
      console.log(e)
      const { Association } = e
      const columnsAssociation = [
        {
          title: 'Disease',
          dataIndex: 'Disease',
          key: 'Disease',
        },

        {
          title: 'Reference',
          dataIndex: 'Reference',
          render: (Reference) => (
            <span>
              {Reference != 'Null' &&
                Reference.map((item, index) => {
                  return (
                    <Tag
                      color="blue"
                      key={index}
                      onClick={() => {
                        this.getReferences2(item.url)
                      }}>
                      {item.name.toUpperCase()}
                    </Tag>
                  )
                })}
            </span>
          ),
        },
      ]
      return (
        <Table
          columns={columnsAssociation}
          rowKey="item"
          dataSource={Association}
          pagination={false}
        />
      )
    }

    const getFieldDecorator2 = this.props.form.getFieldDecorator
    const getFieldValue2 = this.props.form.getFieldValue
    const columns2 = [
      {
        title: 'name',
        dataIndex: 'name',
        key: 'name',
      },
      {
        title: 'identity',
        dataIndex: 'identity',
        key: 'identity',
        render: (item, record) => <div>{item && item + '%'}</div>,
      },
      {
        title: 'similarity',
        dataIndex: 'similarity',
        key: 'similarity',
        render: (item, record) => <div>{item && item + '%'}</div>,
      },
      {
        title: 'sequence',
        dataIndex: 'sequence',
        key: 'sequence',
        render: (item, record) => (
          <div className="table-sequence-div">
            {item.split('').map((item2, index) => {
              return <div key={index}>{item2}</div>
            })}
          </div>
        ),
      },
    ]
    const formItemLayout2 = {
      labelCol: {
        xs: { span: 24 },
        sm: { span: 4 },
      },
      wrapperCol: {
        xs: { span: 24 },
        sm: { span: 20 },
      },
    }
    const formItemLayoutWithOutLabel = {
      wrapperCol: {
        xs: { span: 24, offset: 0 },
        sm: { span: 20, offset: 4 },
      },
    }
    const columnsDrug = [

      {
        title: 'Drug Structure',
        dataIndex: 'Drug structure',
        key: 'Drug structure',
        render: (DrugStructure) => (
          <Jsme
            height="100px"
            width="100px"
            options="depict,useopenchemlib"
            smiles={DrugStructure}
          />
        ),
      },

      {
        title: 'Drug name',
        dataIndex: 'Drug name',
        key: 'Drug name',
        render: (item, record) => (
          <Button type="primary" onClick={() => this.getDrug(record.dataid)}>
            {item}
          </Button>
        ),
      },
      {
        title: 'DrugbankId',
        dataIndex: 'DrugbankId',
        key: 'DrugbankId',
      },
      {
        title: 'Drug Type',
        dataIndex: 'Drug Type',
        key: 'Drug Type',
      },

      {
        title: 'Mechanism of Action',
        dataIndex: 'Mechanism of Action',
        key: 'Mechanism of Action',
        render: (Mechanism) => (
          <span>
            {Mechanism.map((item, index) => {
              return (
                <span key={index}>
                  {' '}
                  {item}
                  {index > 0 && <span> ,</span>}
                </span>
              )
            })}
          </span>
        ),
      },
    ]
    const columnsBioassay = [
      {
        title: 'Structure',
        dataIndex: 'structure',
        key: 'structure',
        render: (structure) => (
          <Jsme
            height="100px"
            width="100px"
            options="depict,useopenchemlib"
            smiles={structure}
          />
        ),
      },
      {
        title: 'Standard Type',
        dataIndex: 'Standard Type',
        key: 'Standard Type',
      },
      {
        title: 'Standard Relation',
        dataIndex: 'Standard Relation',
        key: 'Standard Relation',
      },
      {
        title: 'Standard Value',
        dataIndex: 'Standard Value',
        key: 'Standard Value',
      },
      {
        title: 'Standard Units',
        dataIndex: 'Standard Units',
        key: 'Standard Units',
      },
      {
        title: ' Compound Name',
        dataIndex: 'compound_name',
        key: 'compound_name',
      },

      {
        title: 'reference',
        dataIndex: 'reference',
        key: 'reference',
        render: (reference) => (
          <span>
            {
              <Tag
                color="blue"
                onClick={() => {
                  this.getReferences2(reference)
                }}>
                {reference}
              </Tag>
            }
          </span>
        ),
      },
    ]
    const formItemLayout = {
      labelCol: { span: 8 },
      wrapperCol: { span: 12 },
    }

    const columnsMutation = [
      {
        title: 'Generic number',
        dataIndex: 'Generic',
        key: 'Generic',
      },
      {
        title: 'Position',
        dataIndex: 'Position',
        key: 'Position',
      },
      {
        title: 'Segment',
        dataIndex: 'Segment',
        key: 'Segment',
      },
      {
        title: 'Mutation',
        dataIndex: 'Mutation',
        key: 'Mutation',
      },
      {
        title: 'Ligand',
        dataIndex: 'Ligand',
        key: 'Ligand',
        render: (Ligand, record) => (
          <Popover
            content={
              <div>
                <Jsme
                  height="100px"
                  width="100px"
                  options="depict,useopenchemlib"
                  smiles={Ligand.smile}
                />
              </div>
            }>
            {Ligand.name != '' && <Button type="primary">{Ligand.name}</Button>}
          </Popover>
        ),
      },
      {
        title: 'Activity type',
        dataIndex: 'Activity type',
        key: 'Activity type',
      },
      {
        title: 'Activity value',
        dataIndex: 'Activity value',
        key: 'Activity value',
      },
      {
        title: 'units',
        dataIndex: 'units',
        key: 'units',
      },

      // {
      //   title: 'Year of approval',
      //   dataIndex: 'Year of approval',
      //   key: 'Year of approval',
      // },
      {
        title: 'Reference',
        dataIndex: 'Reference',
        render: (Reference) => (
          <span>
            {
              <Tag
                color="blue"
                onClick={() => {
                  this.getReferences2(Reference)
                }}>
                {Reference.toUpperCase()}
              </Tag>
            }
          </span>
        ),
      },
    ]
    const columnsChain = [
      {
        title: 'Chain_name',
        dataIndex: 'Chain_name',
        key: 'Chain_name',
      },
      {
        title: 'Chain_ID',
        dataIndex: 'Chain_ID',
        key: 'Chain_ID',
      },

      {
        title: 'code',
        dataIndex: 'code',
        key: 'code',
      },
      {
        title: 'code_type',
        dataIndex: 'code_type',
        key: 'code_type',
      },
      {
        title: 'res_start',
        dataIndex: 'res_start',
        key: 'res_start',
      },
      {
        title: 'res_end',
        dataIndex: 'res_end',
        key: 'res_end',
      },
    ]
    const formTailLayout = {
      labelCol: { span: 8 },
      wrapperCol: { span: 12, offset: 8 },
    }
    getFieldDecorator('keys', { initialValue: [] })
    getFieldDecorator2('keys2', { initialValue2: [] })
    const keys = getFieldValue('keys')
    const keys2 = getFieldValue2('keys')
    const formItems = keys.map((k, index) => (
      <Form.Item
        {...(index === 0 ? formItemLayout2 : formItemLayoutWithOutLabel)}
        label={index === 0 ? 'AlignSequence: ' : ''}
        required={false}
        key={k}>
        {getFieldDecorator(`names[${k}]`)(
          <Input
            placeholder="Please input uniprot name"
            style={{ width: '60%', marginRight: 8 }}
          />
        )}
        {keys.length > 1 ? (
          <Icon
            className="dynamic-delete-button"
            type="minus-circle-o"
            onClick={() => this.remove(k)}
          />
        ) : null}
      </Form.Item>
    ))
    const formItems2 = keys2.map((k, index) => (
      <Form.Item
        {...(index === 0 ? formItemLayout2 : formItemLayoutWithOutLabel)}
        label={index === 0 ? 'SelectPDB: ' : ''}
        required={false}
        key={k}>
        <div style={{ display: 'flex ', alignItems: 'center ' }}>
          {getFieldDecorator2(`pdbList[${k}]`)(
            <Select style={{ width: '70px' }}>
              {targetsDetail.Structure.map((item, index) => {
                return (
                  <Option key={index.pdb} value={item.pdb.toLowerCase()}>
                    {item.pdb.toLowerCase()}
                  </Option>
                )
              })}
            </Select>
          )}
          <div>
            <Form.Item style={{ margin: '0px' }}>
              {getFieldDecorator2(`chainList[${k}]`)(
                <Input placeholder="请输入Chain" style={{ width: '100px' }} />
              )}
            </Form.Item>
          </div>
          <div>
            <Form.Item style={{ margin: '0px' }}>
              {getFieldDecorator2(`methodList[${k}]`)(
                <Select style={{ width: '70px' }}>
                  {addList.map((item, index) => {
                    return (
                      <Option key={index} value={item}>
                        {item}
                      </Option>
                    )
                  })}
                </Select>
              )}
            </Form.Item>
          </div>
          <div>
            <Form.Item style={{ margin: '0px' }}>
              {getFieldDecorator2(`cutoffList[${k}]`)(
                <Input placeholder="Cutoff" style={{ width: '70px' }} />
              )}
            </Form.Item>
          </div>
          <div>
            <Form.Item style={{ margin: '0px' }}>
              {getFieldDecorator2(`cyclesList[${k}]`)(
                <Input
                  placeholder="Cycles"
                  style={{ width: '70px', marginRight: 8 }}
                />
              )}
              {keys2.length > 1 ? (
                <Icon
                  className="dynamic-delete-button"
                  type="minus-circle-o"
                  onClick={() => this.remove2(k)}
                />
              ) : null}
            </Form.Item>
          </div>
        </div>
      </Form.Item>
    ))

    return (
      <div className="search-TargetDetails-div">
        <div className="Anchor-div">
          {directoryState && (
            <Button type="primary" style={{ width: '100%' }} onClick={() => this.setState({ directoryState: false })}>
              收起目录
            </Button>
          )}
          {!directoryState && (
            <Button type="primary" style={{ width: '100%' }} onClick={() => this.setState({ directoryState: true })}>

              展开目录
            </Button>
          )}
          {
            directoryState && (
              <div> <Anchor onClick={this.handleAnchorClick}>
                <Link href="#card" title="card" />
                <Link href="#Sequence" title="Sequence" />
                <Link href="#Structure" title="Structure" />
                <Link href="#Mutation" title="Mutation" />
                <Link href="#Drug" title="Drug & Clinical imformation" />
                <Link href="#Bioassay" title="Bioassay" />
              </Anchor></div>
            )

          }

        </div>
        <Modal
          footer={null}
          closable={false}
          width={550}
          visible={visible}
          wrapClassName="vertical-center-modal"
          onCancel={() => this.setState({ visible: false })}>
          <div className="Molstar-div">
            <Molstar file={this.state.fileData} />
          </div>
        </Modal>
        <Modal
          footer={null}
          closable={false}
          width={1000}
          visible={visible2}
          wrapClassName="vertical-center-modal"
          onCancel={this.onCancelForm}>
          <div className="form-div">
            <Form onSubmit={this.handleSubmit}>
              <Form.Item
                label="Ref. Sequence:"
                {...{
                  labelCol: {
                    xs: { span: 24 },
                    sm: { span: 4 },
                  },
                  wrapperCol: {
                    xs: { span: 24 },
                    sm: { span: 20 },
                  },
                }}>
                <Input
                  placeholder=""
                  style={{ width: '60%', marginRight: 8 }}
                  disabled
                  value={targetsDetail.name}
                />
              </Form.Item>

              {formItems}
              <Form.Item {...formItemLayoutWithOutLabel}>
                <Button
                  type="dashed"
                  onClick={this.add}
                  style={{ width: '60%' }}>
                  <Icon type="plus" /> Add field
                </Button>
              </Form.Item>
              <Form.Item {...formItemLayoutWithOutLabel}>
                <Button type="primary" htmlType="submit">
                  Align
                </Button>
              </Form.Item>
            </Form>
          </div>
          <div className="SequenceAlignmentList-div">
            {SequenceAlignmentList.length > 0 && (
              <Table
                bordered
                rowKey="item"
                dataSource={SequenceAlignmentList}
                pagination={false}
                columns={columns2}
                scroll={{ x: 1800 }}
              />
            )}
          </div>
        </Modal>
        <Modal
          footer={null}
          closable={false}
          width={700}
          visible={visible3}
          wrapClassName="vertical-center-modal"
          onCancel={() => this.setState({ visible3: false })}>
          <div className="Molstar-div">
            <Form layout="horizontal">
              <Form.Item label="输入Smiles" {...formItemLayout}>
                <Input
                  placeholder="请输入"
                  style={{ width: 250 }}
                  size="large"
                  onChange={this.getLigendValue}
                  value={this.state.BioassaySearch.drugs_data}
                />
              </Form.Item>
              <Form.Item label="" {...formTailLayout}>
                {/* <Button
                  type="primary"
                  style={{ marginRight: '50px' }}
                  onClick={this.getDraw}>
                  画结构
                </Button> */}
                <Button
                  type="primary"
                  style={{ marginLeft: 50, width: 150 }}
                  size="large"
                  loading={this.state.loading}
                  onClick={this.getBioassayList}>
                  Search
                </Button>
                <div
                  className={true ? 'bottom-div' : 'bottom-div isShowDiv'}
                >
                  <Radio.Group
                    onChange={this.onChangeRadio4}
                    value={this.state.BioassaySearch.finger}>
                    <Radio value={0}>Substructure</Radio>
                    {/* <Radio value={1}>有GPCR相关PDB结构</Radio> */}
                    <Radio value={1}>Similar Structure</Radio>
                  </Radio.Group>
                </div>
                <div
                  className={true ? 'bottom-div' : 'bottom-div isShowDiv'}
                >
                  <Jsme
                    height="300px"
                    width="400px"
                    options="oldlook,star"
                    onChange={this.logSmiles2}
                  />
                </div>
              </Form.Item>
            </Form>
          </div>
        </Modal>

        <Spin tip="Loading..." size="large" spinning={this.state.loading}>
          <Card hoverable id="card">
            <div>
              <div className="title-div">{targetsDetail.name}</div>
              <div className="title-div-top">
                <div className="DataList-left">
                  <div>
                    <div className="div-list">
                      <div className="list-one">
                        <div>Gene name</div>
                        <div />
                        {targetsDetail.Gene_name.map((item) => {
                          return <Tag>{item}</Tag>
                        })


                        }
                      </div>
                      <div className="list-one">
                        <div>Species</div>
                        <div />
                        {targetsDetail.Species}
                      </div>
                      <div className="list-one">
                        <div>Uniprot id</div>
                        <div />
                        {targetsDetail.Uniport_id}
                      </div>
                      {/* <div className="list-one">
                        <div>Class</div>
                        <div />
                        {targetsDetail.Class}
                      </div> */}

                    </div>
                  </div>
                </div>
              </div>
            </div>
          </Card>
          {/* {PanelList} */}
          <Collapse
            defaultActiveKey={['1', '2', '3', '4', '5', '6']}
            onChange={this.callback}>
            <Panel header="Sequence" key="1" id="Sequence">
              <Button type="primary" onClick={this.alignmentEve}>
                alignment
              </Button>
              <div className="Sequence-div">
                {targetsDetail.Sequence &&
                  targetsDetail.Sequence.map((item, index) => {
                    // console.log(item);
                    //   console.log(Object.entries(item));
                    return (
                      <div className="Sequenceone-div" key={index}>
                        {Object.entries(item)[0][0]}
                        <div className="zimu-div">
                          {Object.entries(item)[0][1].map((item2, index2) => {
                            return (
                              <Tooltip
                                placement="top"
                                key={index2}
                                title={item2.title}>
                                <div className={'res-color-' + item2.thum}>
                                  {item2.thum}
                                </div>
                              </Tooltip>
                            )
                          })}
                        </div>
                      </div>
                    )
                  })}
              </div>
            </Panel>
            <Panel header="Structure" key="2" id="Structure">
              <Tabs
                defaultActiveKey="0"
                tabPosition="left"
                style={{ height: 1000 }}
                onChange={this.ChangeTabs}>
                {targetsDetail.Structure.map((item, index) => {
                  return (
                    <TabPane tab={item.pdb} key={item.pdb} id={item.pdb}>
                      <div className="TabPane-center">
                        <div className="Molstar-div2">
                          {this.state.aciveKey == item.pdb && (
                            <WrappedIframe pdbLink={this.state.pdbLink} />
                          )}
                        </div>
                        <div className="Structure-right">
                          <Form layout="horizontal">
                            <Form.Item label="详情" {...formItemLayout}>
                              <div>method: {getStructureList.method}</div>
                              <div>name: {getStructureList.name}</div>
                              <div>
                                pdb_datatime:{' '}
                                {getStructureList.pdb_datatime}
                              </div>
                              <div>
                                resolution: {getStructureList.resolution}
                              </div>
                            </Form.Item>
                            <Form.Item
                              label="References "
                              {...formItemLayout}>
                              {getStructureList.References &&
                                getStructureList.References.map(
                                  (item, index) => {
                                    return (
                                      <Button
                                        type="primary"
                                        onClick={() => {
                                          this.getReferences2(item)
                                        }}
                                        key={index}
                                        style={{ marginRight: '5px' }}>
                                        {item}
                                      </Button>
                                    )
                                  }
                                )}
                            </Form.Item>
                          </Form>
                          <Collapse accordion>
                            <Panel header="对齐" key="1">
                              <div className="form-div">
                                <Form
                                  onSubmit={this.handleSubmit2}
                                  className="login-form">
                                  <Form.Item
                                    label="Ref.PDB"
                                    {...formItemLayout2}>
                                    <div>
                                      <Select
                                        style={{ width: '100px' }}
                                        value={
                                          this.state.superpositionData[0].pdbID
                                        }
                                        onChange={this.SelectValue}>
                                        {targetsDetail.Structure.map(
                                          (item, index) => {
                                            return (
                                              <Option
                                                key={index}
                                                value={item.pdb.toLowerCase()}>
                                                {item.pdb.toLowerCase()}
                                              </Option>
                                            )
                                          }
                                        )}
                                      </Select>
                                      <Input
                                        placeholder="请输入Chain"
                                        onChange={this.getValue}
                                        value={
                                          this.state.superpositionData[0]
                                            .chainID
                                        }
                                        style={{
                                          width: '100px',
                                        }}
                                      />
                                    </div>
                                  </Form.Item>
                                  {formItems2}
                                  <Form.Item {...formItemLayoutWithOutLabel}>
                                    {sum < 2 && (
                                      <Button
                                        type="dashed"
                                        onClick={this.add2}
                                        style={{ width: '60%' }}>
                                        <Icon type="plus" /> Add field
                                      </Button>
                                    )}
                                  </Form.Item>
                                  <Form.Item {...formItemLayoutWithOutLabel}>
                                    <Button type="primary" htmlType="submit">
                                      对齐
                                    </Button>
                                  </Form.Item>
                                </Form>
                              </div>
                            </Panel>
                            <Panel header="抽取配体" key="2">
                              <Form layout="horizontal">

                                <Form.Item label="配体列表" {...formItemLayout}>
                                  {getStructureList.ligand_up_list &&
                                    getStructureList.ligand_up_list.map(
                                      (item, index) => {
                                        return (
                                          <Popover
                                            content={
                                              <div>
                                                <div
                                                  key={index}
                                                  style={{
                                                    width: '100px',
                                                    wordWrap: 'break-word',
                                                    wordBreak: 'normal',
                                                  }}>
                                                  {item.comp_name}
                                                </div>

                                                <Jsme
                                                  height="100px"
                                                  width="100px"
                                                  options="depict,useopenchemlib"
                                                  smiles={item.smiles}
                                                />
                                              </div>
                                            }>
                                            {
                                              <Button
                                                type="primary"
                                                style={{ marginRight: '5px' }}>
                                                {item.name}
                                              </Button>
                                            }
                                          </Popover>
                                        )
                                      }
                                    )}
                                </Form.Item>
                                <Form.Item label="配体选择" {...formItemLayout}>
                                  <Select
                                    style={{ width: 250 }}
                                    value={this.state.listData.ligand}
                                    size="large"
                                    onChange={this.LigandChange}>
                                    {getStructureList.ligand_list &&
                                      getStructureList.ligand_list.map(
                                        (item, index) => {
                                          return (
                                            <Option key={index} value={item}>
                                              {item}
                                            </Option>
                                          )
                                        }
                                      )}
                                  </Select>
                                </Form.Item>
                                <Form.Item label="搜索半径" {...formItemLayout}>
                                  <InputNumber
                                    style={{ width: 250 }}
                                    min={getStructureList.resolution}
                                    max={10}
                                    placeholder={'请输入大于resolutiond数字'}
                                    step={0.1}
                                    size="large"
                                    onChange={this.getResolutionData}
                                  />
                                </Form.Item>
                                <Form.Item label="Search" {...formItemLayout}>
                                  <Button
                                    type="primary"
                                    style={{ marginLeft: 50, width: 150 }}
                                    size="large"
                                    loading={this.state.loading}
                                    disabled={
                                      getStructureList.ligand_list.length === 0
                                    }
                                    onClick={this.getList}>
                                    Search
                                  </Button>
                                </Form.Item>
                              </Form>
                            </Panel>
                          </Collapse>
                        </div>
                      </div>
                      <Table
                        bordered
                        rowKey="item"
                        dataSource={getStructureList.chain}
                        pagination={false}
                        columns={columnsChain}
                      />
                    </TabPane>
                  )
                })}
              </Tabs>
            </Panel>
            <Panel header="Mutation" key="3" id="Mutation">
              <div className="Radio-div">
                <Radio.Group
                  onChange={this.onChangeRadio}
                  value={this.state.MutationSearch.status}>
                  <Radio value={0}>Full data</Radio>
                  <Radio value={1}>Increase only</Radio>
                  <Radio value={2}>Decrease only</Radio>
                </Radio.Group>
              </div>

              <Table
                bordered
                rowKey="item"
                dataSource={targetsDetail.MutationList}
                pagination={false}
                columns={columnsMutation}
                onChange={this.onChangeTable}
              />
              <Pagination
                showSizeChanger
                onShowSizeChange={this.onShowSizeChange}
                onChange={this.onChange}
                total={total_num}
              />
            </Panel>
            <Panel header="Drug & Clinical imformation" key="4" id="Drug">
              <Table
                bordered
                rowKey="item"
                dataSource={targetsDetail.DrugsInformation}
                pagination={false}
                expandedRowRender={expandedRowRender}
                columns={columnsDrug}
              />
              <Pagination
                showSizeChanger
                onShowSizeChange={this.onShowSizeChange3}
                onChange={this.onChange3}
                total={total_num3}
              />
            </Panel>
            <Panel header="Bioassay" key="5" id="Bioassay">
              <Button type="primary" onClick={() => this.setState({ visible3: true })}>
                Structure Filter
              </Button>
              <Table
                bordered
                rowKey="item"
                dataSource={targetsDetail.Bioassay}
                pagination={false}
                columns={columnsBioassay}
              />
              <Pagination
                showSizeChanger
                onShowSizeChange={this.onShowSizeChange2}
                onChange={this.onChange2}
                total={total_num2}
              />
            </Panel>
            <Panel header="Virants & Disease" key="6" id="VirantsDisease">
              <Table
                bordered
                rowKey="item"
                dataSource={VirantsDiseaseList}
                pagination={false}
                columns={columnsVirantsDisease}
                expandedRowRender={expandedRowRender2}
              />
              <Pagination
                showSizeChanger
                onShowSizeChange={this.onShowSizeChange5}
                onChange={this.onChange5}
                total={total_num5}
              />
            </Panel>
          </Collapse>
        </Spin>
      </div>
    )
  }
}
