import React, { Component } from 'react';
import { Card, Tooltip, message, Button, Tabs, Spin, Table, Tag, Collapse, Input, Modal, Form, Select, InputNumber, Popover, Pagination, Anchor, Icon, Badge, Menu, Dropdown } from 'antd';
import WrappedIframe from '../../../components/iframePdb';
import request from '../../../utils/request';
import Molstar from 'molstar-react';
import { Jsme } from 'jsme-react';
import qs from 'qs';
import './index.css';
const { Panel } = Collapse;
const { TabPane } = Tabs;
const { Option } = Select;
const { Link } = Anchor;
let id = 0;

@Form.create()
export default class SearchDetails extends Component {
  state = {
    name: '',
    dataOne: qs.parse(this.props.location.search.slice(1)),
    visible: false,
    pdbId: '6f6s',
    smile: 'c',
    DetailsData: {
      smiles: null,
      Structure: [],
      Bioassay: [],
      Target: [],
      Indication: [],
      synonyms: [],
    },
    panelList: {},
    loading: true,
    getStructureList: {
      ligand_up_list: [],
      ligand_list: [],
      chain: [],
      References: [],
    },
    listData: {
      pdb_code: '',
      ligand: '',
      resolution: 0,
    },
    fileData: {
      filestring: '',
      type: 'pdb',
    },

    targetsDetail: {
      Target: [],

      Structure: [],
    },
    Biological_propeties: {},
    Calculated_propeties: {},
    BioassaySearch: {
      page: 1,
      page_size: 10,
      dataid: qs.parse(this.props.location.search.slice(1)).dataid,
    },
    TargetSearch: {
      page: 1,
      page_size: 10,
      dataid: qs.parse(this.props.location.search.slice(1)).dataid,
    },
    IndicationSearch: {
      page: 1,
      page_size: 10,
      dataid: qs.parse(this.props.location.search.slice(1)).dataid,
    },
    pdbLink: '',
    pdbLink2: '',
    addList: ['super', 'align'],
    sum: 0,
    // superpositionData: [
    //   {
    //     chainID: "R",
    //     pdbID: "7tyn",
    //   },
    //   {
    //     chainID: "R",
    //     pdbID: "7tyi",
    //     method: "super",
    //     cutoff: 2.0,
    //     cycles: 5,
    //   },
    //   {
    //     chainID: "R",
    //     pdbID: "7vuj",
    //     method: "align",
    //     cutoff: 3.0,
    //     cycles: 4,
    //   },
    // ],
    superpositionData: [
      {
        chainID: '',
        pdbID: '',
      },
      {
        chainID: '',
        pdbID: '',
        method: '',
        cutoff: 0,
        cycles: 0,
      },
      {
        chainID: '',
        pdbID: '',
        method: '',
        cutoff: 0,
        cycles: 0,
      },
    ],

    total_num: 0,
    total_num2: 0,
    total_num3: 0,
    aciveKey: '',
    directoryState: false,
  };
  componentDidMount() {
    this.getDetails();
  }
  getDetails() {
    // this.setState({loading:true})
    this.setState({ loading: true });
    request
      .post('kinase/drug_detail', qs.parse(this.props.location.search.slice(1)))
      .then((res) => {
        this.setState({ loading: false });
        if (res.data.code === 200) {
          let data = res.data.data;
          console.log(data);
          this.setState({
            DetailsData: data,
          });
          this.setState({ Calculated_propeties: data.Calculated_propeties });
          this.setState({ Biological_propeties: data.biological_propeties });

          this.setState({ loading: false });

          let StructureList = data.Structure;
          if (StructureList.length > 0) {
            this.getStructure(StructureList[0].pdb);
            this.setState({
              aciveKey: StructureList[0].pdb,
            });
          }
          this.getBioassayList();
          this.getTargetList();
          this.getIndicationList();
        } else {
          message.error(res.data.msg);
        }
      })
      .catch((err) => {
        console.error(err);
      });
  }
  getStructure = (e) => {
    console.log(e);
    request
      .post(
        '/search_pdb_data',
        qs.stringify({
          pdb: e,
        })
      )
      .then((res) => {
        this.setState({ loading: false });
        if (res.data.code === 200) {
          this.setState({ getStructureList: res.data.data });
          let listData = this.state.listData;
          listData.pdb_code = res.data.data.name;
          listData.ligand = '';
          listData.resolution = 0;
          this.setState({ listData });
          let pdbLink = 'http://52.83.169.190:3004/?id=' + JSON.stringify(listData);
          this.setState({
            pdbLink,
          });
        } else {
          message.error(res.data.msg);
        }
      })
      .catch((err) => {
        console.error(err);
      });
  };
  ChangeTabs = (e) => {
    this.setState({
      aciveKey: e,
    });
    this.setState({
      pdbLink: '',
    });
    let listData = this.state.listData;
    listData.ligand = '';
    listData.resolution = 0;
    if (listData.pdbList) {
      delete listData.pdbList;
    }
    this.setState({
      listData: listData,
      pdbLink: '',
    });
    this.getStructure(e);
  };
  getPdid(e) {
    console.log(e);
    this.setState({ visible: true });
    this.setState({ pdbId: e });
  }
  getTag = (e) => {
    let listData = this.state.listData;
    listData.pdb_code = e;
    listData.ligand = '';
    listData.resolution = 0;
    this.setState({ listData });
    let pdbLink2 = 'http://52.83.169.190:3004/?id=' + JSON.stringify(listData);
    this.setState({
      pdbLink2,
    });
    this.setState({ visible: true });
    this.setState({ pdbId: e });
  };
  getReferences = (e) => {
    window.open(`https://pubmed.ncbi.nlm.nih.gov/${e}`);
  };
  getReferences2 = (e) => {
    window.open(e);
  };
  getList = () => {
    console.log('getList');
    if (this.state.listData.ligand === '') {
      message.warning('输入查询条件');
      return;
    }
    JSON.stringify(this.state.listData);
    let listData = this.state.listData;
    listData.pdbList = this.state.pdbList;
    let pdbLink = 'http://52.83.169.190:3004/?id=' + JSON.stringify(listData);
    this.setState({
      pdbLink,
    });
  };
  getResolutionData = (e) => {
    let listData = this.state.listData;
    listData.resolution = e;
    this.setState({
      listData,
    });
  };
  LigandChange = (e) => {
    let listData = this.state.listData;
    listData.ligand = e;
    this.setState({
      listData,
    });
  };

  callback() {}
  getOne(e) {
    console.log(e);
    const { dataid } = e;
    let data = {
      dataid,
    };

    this.props.history.push({
      pathname: '/kinase/TargetDetails',
      search: qs.stringify(data),
    });
  }
  getBioassayList = () => {
    console.log(this.state.dataOne);
    const { dataid } = this.state.dataOne;
    this.setState({ loading: true });
    request
      .post('kinase/drug_detail/bioassay', this.state.BioassaySearch)
      .then((res) => {
        this.setState({ loading: false });
        if (res) {
          console.log(res);
          let DetailsData = this.state.DetailsData;
          DetailsData.Bioassay = res.data.data;
          this.setState({ total_num2: res.data.total_num });
          this.setState({
            DetailsData: DetailsData,
          });
        }
      })
      .catch((err) => {
        console.error(err);
      });
  };
  getTargetList = () => {
    console.log(this.state.dataOne);
    const { dataid } = this.state.dataOne;
    this.setState({ loading: true });
    request
      .post('kinase/drug_detail/target', this.state.TargetSearch)
      .then((res) => {
        this.setState({ loading: false });
        if (res) {
          console.log(res);
          let DetailsData = this.state.DetailsData;
          DetailsData.Target = res.data.data;
          this.setState({ total_num: res.data.total_num });
          this.setState({
            DetailsData: DetailsData,
          });
        }
      })
      .catch((err) => {
        console.error(err);
      });
  };
  getIndicationList = () => {
    console.log(this.state.dataOne);
    const { dataid } = this.state.dataOne;
    this.setState({ loading: true });
    request
      .post('kinase/drug_detail/indication', this.state.IndicationSearch)
      .then((res) => {
        this.setState({ loading: false });
        if (res) {
          console.log(res);
          let DetailsData = this.state.DetailsData;
          DetailsData.Indication = res.data.data;
          this.setState({ total_num3: res.data.total_num });
          this.setState({
            DetailsData: DetailsData,
          });
        }
      })
      .catch((err) => {
        console.error(err);
      });
  };
  onShowSizeChange = (current, pageSize) => {
    let BioassaySearch = this.state.BioassaySearch;
    BioassaySearch.page = current;
    BioassaySearch.page_size = pageSize;
    this.setState({
      BioassaySearch,
    });
    this.getBioassayList();
  };
  onChange = (current, pageSize) => {
    let BioassaySearch = this.state.BioassaySearch;
    BioassaySearch.page = current;
    BioassaySearch.page_size = pageSize;
    this.setState({
      BioassaySearch,
    });

    this.getBioassayList();
  };
  onShowSizeChange2 = (current, pageSize) => {
    console.log(current, pageSize);
    let TargetSearch = this.state.TargetSearch;
    TargetSearch.page = current;
    TargetSearch.page_size = pageSize;
    this.setState({
      TargetSearch,
    });
    this.getTargetList();
  };
  onChange2 = (current, pageSize) => {
    console.log(current, pageSize);
    let TargetSearch = this.state.TargetSearch;
    TargetSearch.page = current;
    TargetSearch.page_size = pageSize;
    this.setState({
      TargetSearch,
    });
    this.getTargetList();
  };
  onShowSizeChange3 = (current, pageSize) => {
    console.log(current, pageSize);
    let IndicationSearch = this.state.IndicationSearch;
    IndicationSearch.page = current;
    IndicationSearch.page_size = pageSize;
    this.setState({
      IndicationSearch,
    });
    this.getIndicationList();
  };
  onChange3 = (current, pageSize) => {
    console.log(current, pageSize);
    let IndicationSearch = this.state.IndicationSearch;
    IndicationSearch.page = current;
    IndicationSearch.page_size = pageSize;
    this.setState({
      IndicationSearch,
    });
    this.getIndicationList();
  };
  handleAnchorClick = (e) => {
    e.preventDefault();
  };
  getValue = (e) => {
    const { value } = e.target;
    let superpositionData = this.state.superpositionData;
    superpositionData[0].chainID = value;
    this.setState(() => ({ superpositionData: superpositionData }));
  };
  SelectValue = (e) => {
    console.log(e);
    let superpositionData = this.state.superpositionData;
    superpositionData[0].pdbID = e;
    this.setState(() => ({ superpositionData: superpositionData }));
  };
  onChangeGroup = (e) => {
    console.log(e);
    this.setState({
      pdbList: e,
    });
  };
  remove = (k) => {
    const { form } = this.props;
    // can use data-binding to get
    const keys = form.getFieldValue('keys');
    // We need at least one passenger
    if (keys.length === 1) {
      return;
    }

    this.setState({
      sum: keys.length - 1,
    });

    // can use data-binding to set
    form.setFieldsValue({
      keys: keys.filter((key) => key !== k),
    });
  };

  add = () => {
    const { form } = this.props;
    // can use data-binding to get
    const keys = form.getFieldValue('keys');
    console.log(keys);
    const nextKeys = keys.concat(id++);
    // can use data-binding to set
    // important! notify form to detect changes
    form.setFieldsValue({
      keys: nextKeys,
    });
    this.setState({
      sum: keys.length + 1,
    });
  };

  handleSubmit = (e) => {
    // console.log(e);
    // e.preventDefault();
    this.props.form.validateFields((err, values) => {
      console.log(values);
      const { keys, pdbList, chainList, methodList, cutoffList, cyclesList } = values;
      console.log('Received values of form: ', values);
      // console.log('Merged values:', keys.map(key => names[key]))
      // let names = keys.map(key => names[key])

      for (let index = 0; index < pdbList.length; index++) {
        var element = pdbList[index];
        if (element == undefined) {
          pdbList[index] = '';
        }
      }
      let newArr = pdbList.filter((i) => i && i.trim());
      for (let index = 0; index < chainList.length; index++) {
        var element = chainList[index];
        if (element == undefined) {
          chainList[index] = '';
        }
      }
      let newArr2 = chainList.filter((i) => i && i.trim());
      for (let index = 0; index < methodList.length; index++) {
        var element = methodList[index];
        if (element == undefined) {
          methodList[index] = '';
        }
      }
      let newArr3 = methodList.filter((i) => i && i.trim());
      for (let index = 0; index < cutoffList.length; index++) {
        var element = cutoffList[index];
        if (element == undefined) {
          cutoffList[index] = '';
        }
      }
      let newArr4 = cutoffList.filter((i) => i && i.trim());
      for (let index = 0; index < cyclesList.length; index++) {
        var element = cyclesList[index];
        if (element == undefined) {
          cyclesList[index] = '';
        }
      }
      let newArr5 = cyclesList.filter((i) => i && i.trim());
      console.log(newArr2);
      let superpositionData = this.state.superpositionData;
      superpositionData[1].pdbID = newArr[0] === undefined ? '' : newArr[0];
      superpositionData[1].chainID = newArr2[0] === undefined ? '' : newArr2[0];
      superpositionData[1].method = newArr3[0] === undefined ? '' : newArr3[0];
      superpositionData[1].cutoff = newArr4[0] === undefined ? '' : parseInt(newArr4[0]);
      superpositionData[1].cycles = newArr5[0] === undefined ? '' : parseInt(newArr5[0]);
      superpositionData[2].pdbID = newArr[1] === undefined ? '' : newArr[1];
      superpositionData[2].chainID = newArr2[1] === undefined ? '' : newArr2[1];
      superpositionData[2].method = newArr3[1] === undefined ? '' : newArr3[1];
      (superpositionData[2].cutoff = newArr4[1] === undefined ? '' : parseInt(newArr4[1])), (superpositionData[2].cycles = newArr5[1] === undefined ? '' : parseInt(newArr5[1]));
      this.setState(() => ({ superpositionData: superpositionData }));
      console.log(this.state.superpositionData);
      let listData = this.state.listData;
      listData.pdbList = this.state.superpositionData;
      let pdbLink = 'http://52.83.169.190:3004/?id=' + JSON.stringify(listData);
      this.setState({ listData });
      this.setState({ pdbLink });
      console.log(this.state.pdbLink);
    });
  };
  render() {
    const {
      visible,
      panelList,
      name,
      pdbId,
      DetailsData,
      getStructureList,
      targetsDetail,
      total_num,
      total_num2,
      total_num3,
      Calculated_propeties,
      Biological_propeties,
      pdbLink,
      pdbLink2,
      addList,
      sum,
      directoryState,
    } = this.state;
    const formItemLayout = {
      labelCol: { span: 8 },
      wrapperCol: { span: 12 },
    };
    const columns = [
      {
        title: 'Target name',
        dataIndex: 'Target name',
        key: 'Target name',
        render: (item, record) => (
          <Tag
            color='blue'
            onClick={() => {
              this.getOne(record);
            }}
          >
            {record.Target_name}
          </Tag>
        ),
      },

      {
        title: 'Uniport id',
        dataIndex: 'Uniport_id',
        key: 'Uniport_id',
      },
      {
        title: 'Group',
        dataIndex: 'Group',
        key: 'Group',
      },
      {
        title: 'Family',
        dataIndex: 'Family',
        key: 'Family',
      },
      {
        title: 'PDB',
        dataIndex: 'PDB',
        render: (PDB) => (
          <span>
            {PDB.map((item, index) => {
              return (
                <Tag
                  color='blue'
                  key={index}
                  onClick={() => {
                    this.getTag(item);
                  }}
                >
                  {item.toUpperCase()}
                </Tag>
              );
            })}
          </span>
        ),
      },
      {
        title: 'sequence',
        dataIndex: 'sequence',
        key: 'sequence',
        render: (sequence) => (
          <span>
            {
              <Tooltip placement='topLeft' title={sequence}>
                <Button>Sequence</Button>
              </Tooltip>
            }
          </span>
        ),
      },
    ];
    const columns2 = [
      {
        title: 'Indication',
        dataIndex: 'Indication',
        key: 'Indication',
      },
      {
        title: 'Synonyms',
        dataIndex: 'Synonyms',
        key: 'Synonyms',
        render: (Synonyms) => (
          <span>
            {Synonyms != null &&
              Synonyms.map((item, index) => {
                return <span key={index}>{item.toUpperCase()},</span>;
              })}
          </span>
        ),
      },
      {
        title: 'Status',
        dataIndex: 'Status',
        key: 'Status',
        render: (Status) => (
          <span>
            {Status.map((item, index) => {
              return <Tag key={index}>{item.toUpperCase()}</Tag>;
            })}
          </span>
        ),
      },
      {
        title: 'Clinical phase',
        dataIndex: 'Clinical_phase',
        key: 'Clinical_phase',
      },
      {
        title: 'Clinical status',
        dataIndex: 'Clinical_status',
        key: 'Clinical_status',
      },
      {
        title: 'Purpose',
        dataIndex: 'Purpose',
        key: 'Purpose',
      },
      {
        title: 'reference',
        dataIndex: 'reference',
        render: (reference) => (
          <span>
            {reference != 'Null' &&
              reference.map((item, index) => {
                return (
                  <Tag
                    color='blue'
                    key={index}
                    onClick={() => {
                      this.getReferences2(item);
                    }}
                  >
                    {item.toUpperCase()}
                  </Tag>
                );
              })}
          </span>
        ),
      },
    ];
    const menu = (
      <Menu>
        <Menu.Item>Action 1</Menu.Item>
        <Menu.Item>Action 2</Menu.Item>
      </Menu>
    );
    const expandedRowRender = (e) => {
      console.log(e);
      const { standards } = e;
      const columns = [
        {
          title: 'Standard Type',
          dataIndex: 'Standard Type',
          key: 'Standard Type',
        },
        {
          title: 'Standard Relation',
          dataIndex: 'Standard Relation',
          key: 'Standard Relation',
        },
        {
          title: 'Standard Value',
          dataIndex: 'Standard Value',
          key: 'Standard Value',
        },
        {
          title: 'Standard Units',
          dataIndex: 'Standard Units',
          key: 'Standard Units',
        },
        {
          title: 'reference',
          dataIndex: 'reference',
          key: 'reference',
          render: (reference) => (
            <span>
              {
                <Tag
                  color='blue'
                  onClick={() => {
                    this.getReferences2(reference);
                  }}
                >
                  {reference}
                </Tag>
              }
            </span>
          ),
        },
      ];
      return <Table columns={columns} dataSource={standards} pagination={false} />;
    };

    const columns3 = [
      {
        title: 'Target',
        dataIndex: 'Target',
        render: (item, record) => (
          <Tag
            color='blue'
            onClick={() => {
              this.getOne(record);
            }}
          >
            {record.Target_name}
          </Tag>
        ),
      },

      // {
      //   title: 'Reference',
      //   dataIndex: 'reference',
      //   key: 'reference',
      //   render: (reference) => (
      //     <span>
      //       {reference &&
      //         reference.map((item, index) => {
      //           return (
      //             <Tag
      //               color="blue"
      //               key={index}
      //               onClick={() => {
      //                 this.getReferences(item)
      //               }}>
      //               {item.toUpperCase()}
      //             </Tag>
      //           )
      //         })}
      //     </span>
      //   ),
      // },
    ];
    const columnsChain = [
      {
        title: 'Chain_name',
        dataIndex: 'Chain_name',
        key: 'Chain_name',
      },
      {
        title: 'Chain_ID',
        dataIndex: 'Chain_ID',
        key: 'Chain_ID',
      },

      {
        title: 'code',
        dataIndex: 'code',
        key: 'code',
      },
      {
        title: 'code_type',
        dataIndex: 'code_type',
        key: 'code_type',
      },
      {
        title: 'res_start',
        dataIndex: 'res_start',
        key: 'res_start',
      },
      {
        title: 'res_end',
        dataIndex: 'res_end',
        key: 'res_end',
      },
    ];
    const { getFieldDecorator, getFieldValue } = this.props.form;
    const formItemLayoutWithOutLabel = {
      wrapperCol: {
        xs: { span: 24, offset: 0 },
        sm: { span: 20, offset: 4 },
      },
    };
    const formItemLayout2 = {
      labelCol: {
        xs: { span: 24 },
        sm: { span: 4 },
      },
      wrapperCol: {
        xs: { span: 24 },
        sm: { span: 20 },
      },
    };
    getFieldDecorator('keys', { initialValue: [] });
    const keys = getFieldValue('keys');
    const formItems = keys.map((k, index) => (
      <Form.Item {...(index === 0 ? formItemLayout2 : formItemLayoutWithOutLabel)} label={index === 0 ? 'SelectPDB: ' : ''} required={false} key={k}>
        <div style={{ display: 'flex ', alignItems: 'center ' }}>
          {getFieldDecorator(`pdbList[${k}]`)(
            <Select style={{ width: '100px' }}>
              {DetailsData.Structure.map((item, index) => {
                return (
                  <Option key={index.pdb} value={item.pdb.toLowerCase()}>
                    {item.pdb.toLowerCase()}
                  </Option>
                );
              })}
            </Select>
          )}
          <div>
            <Form.Item style={{ margin: '0px' }}>{getFieldDecorator(`chainList[${k}]`)(<Input placeholder='请输入Chain' style={{ width: '100px', marginRight: 8 }} />)}</Form.Item>
          </div>
          <div>
            <Form.Item style={{ margin: '0px' }} help='The information is being validated...'>
              {getFieldDecorator(`methodList[${k}]`)(
                <Select style={{ width: '100px' }}>
                  {addList.map((item, index) => {
                    return (
                      <Option key={index} value={item}>
                        {item}
                      </Option>
                    );
                  })}
                </Select>
              )}
            </Form.Item>
          </div>
          <div>
            <Form.Item style={{ margin: '0px' }}>{getFieldDecorator(`cutoffList[${k}]`)(<Input placeholder='Cutoff' style={{ width: '100px', marginRight: 8 }} />)}</Form.Item>
          </div>
          <div>
            <Form.Item style={{ margin: '0px' }}>
              {getFieldDecorator(`cyclesList[${k}]`)(<Input placeholder='Cycles' style={{ width: '100px', marginRight: 8 }} />)}
              {keys.length > 1 ? <Icon className='dynamic-delete-button' type='minus-circle-o' onClick={() => this.remove(k)} style={{ marginLeft: '10px' }} /> : null}
            </Form.Item>
          </div>
        </div>
      </Form.Item>
    ));
    return (
      <div className='search-details-div'>
        <Modal footer={null} closable={false} width={850} visible={visible} wrapClassName='vertical-center-modal' onCancel={() => this.setState({ visible: false })}>
          <div className='Molstar-div'>
            {/* <Molstar file={this.state.fileData} /> */}
            <iframe src={pdbLink2} height={'500px'} width={'100%'} name='iframe-video' />
          </div>
        </Modal>
        <Spin tip='Loading...' size='large' spinning={this.state.loading}>
          <div className='Anchor-div'>
            {directoryState && (
              <Button type='primary' style={{ width: '100%' }} onClick={() => this.setState({ directoryState: false })}>
                收起目录
              </Button>
            )}
            {!directoryState && (
              <Button type='primary' style={{ width: '100%' }} onClick={() => this.setState({ directoryState: true })}>
                展开目录
              </Button>
            )}

            {directoryState && (
              <div>
                <Anchor onClick={this.handleAnchorClick}>
                  <Link href='#card' title='Title' />
                  <Link href='#Indication' title='Indication' />
                  <Link href='#Target' title='Target' />
                  <Link href='#BiologicalPropeties' title='Biological Propeties' />
                  <Link href='#Bioassay' title='Bioassay' />
                  <Link href='#CalculatedPropeties' title='Calculated Propeties' />
                  <Link href='#Structure' title='Structure' />
                </Anchor>
              </div>
            )}
          </div>
          <Card hoverable id='card'>
            <div>
              <div className='title-div'>{name}</div>
              <div className='title-div-top'>
                <div className='DataList-left'>
                  <div>
                    <div className='title-div'>{DetailsData.name}</div>
                    <div className='title-div-top'>
                      <div className='DataList-left'>
                        <div>
                          <div className='div-list'>
                            <div className='list-one'>
                              <div className='left-title'>Synonyms</div>

                              <div className='Synonyms-div'>
                                <div> </div>
                                {DetailsData.synonyms.map((item, index) => {
                                  return <Tag key={index}>{item}</Tag>;
                                })}
                              </div>
                            </div>
                            <div className='list-one'>
                              <div className='left-title'>Drug Type</div>
                              <div />
                              {DetailsData.datatype}
                            </div>
                            <div className='list-one'>
                              <div className='left-title'>Smiles</div>
                              <div />
                              {DetailsData.smiles}
                            </div>
                          </div>
                        </div>
                      </div>
                      <div className='Jsme-div'>{DetailsData.smiles && <Jsme height='300px' width='300px' options='depict,useopenchemlib' smiles={DetailsData.smiles} />}</div>
                    </div>
                  </div>
                </div>
              </div>
            </div>
          </Card>
          <Collapse defaultActiveKey={['1', '2', '3', '4', '5', '6']} onChange={this.callback}>
            <Panel header='Indication' id='Indication' key='6'>
              <Table bordered rowKey='dataid' dataSource={DetailsData.Indication} pagination={false} columns={columns2} />
              <Pagination showSizeChanger onShowSizeChange={this.onShowSizeChange3} onChange={this.onChange3} total={total_num3} />
            </Panel>
            <Panel header='Target' key='1' id='Target'>
              <Table bordered rowKey='index' dataSource={DetailsData.Target} pagination={false} columns={columns} />
              <Pagination showSizeChanger onShowSizeChange={this.onShowSizeChange2} onChange={this.onChange2} total={total_num} />
            </Panel>
            <Panel header='Biological Propeties' id='BiologicalPropeties' key='5'>
              <div className='Calcilated'>
                <div className='div-list'>
                  <div className='list-one'>
                    <div>Absorption:</div>
                    <div />
                    {Biological_propeties.absorption}
                  </div>
                  <div className='list-one'>
                    <div>Clearance:</div>
                    <div />
                    {Biological_propeties.clearance}
                  </div>
                  <div className='list-one'>
                    <div>Distribution: </div>
                    <div />
                    {Biological_propeties.distribution}
                  </div>
                  <div className='list-one'>
                    <div>Elimination:</div>
                    <div />
                    {Biological_propeties.elimination}
                  </div>
                  <div className='list-one'>
                    <div>Half Life: </div>
                    <div />
                    {Biological_propeties.half_life}
                  </div>
                  <div className='list-one'>
                    <div>metabolism: </div>
                    <div />
                    {Biological_propeties.metabolism}
                  </div>
                  <div className='list-one'>
                    <div>Toxicity: </div>
                    <div />
                    {Biological_propeties.toxicity}
                  </div>
                </div>
              </div>
            </Panel>

            <Panel header='Bioassay' key='2' id='Bioassay'>
              <Table bordered rowKey='dataid' dataSource={DetailsData.Bioassay} pagination={false} columns={columns3} expandedRowRender={expandedRowRender} />
              <Pagination showSizeChanger onShowSizeChange={this.onShowSizeChange} onChange={this.onChange} total={total_num2} />
            </Panel>
            <Panel header='Calculated Propeties' key='3' id='CalculatedPropeties'>
              <div>
                <div className='Calcilated'>
                  <div className='list-one2'>
                    <div>Molecular weight:</div>
                    <div />
                    {Calculated_propeties.Molecular_weight}
                  </div>
                  <div className='list-one2'>
                    <div>LogP:</div>
                    <div />
                    {Calculated_propeties.logP}
                  </div>
                  <div className='list-one2'>
                    <div>Hydrogen bond donor: </div>
                    <div />
                    {Calculated_propeties.Hydrogen_bond_donor}
                  </div>
                  <div className='list-one2'>
                    <div>Hydrogen bond acceptor:</div>
                    <div />
                    {Calculated_propeties.Hydrogen_bond_acceptor}
                  </div>
                  <div className='list-one2'>
                    <div>Rotatable bond: </div>
                    <div />
                    {Calculated_propeties.Rotatable_bond}
                  </div>
                  <div className='list-one2'>
                    <div>sp3 Carbon: </div>
                    <div />
                    {Calculated_propeties.sp3_Carbon}
                  </div>
                  <div className='list-one2'>
                    <div>tPSA: </div>
                    <div />
                    {Calculated_propeties.tPSA}
                  </div>
                </div>
              </div>
            </Panel>
            <Panel header='Structure' key='4' id='Structure'>
              <Tabs
                defaultActiveKey='0'
                // type="card"
                style={{ height: 1000 }}
                tabPosition='left'
                onChange={this.ChangeTabs}
              >
                {DetailsData.Structure.map((item, index) => {
                  return (
                    <TabPane id={item.pdb} tab={item.pdb} key={item.pdb}>
                      <div className='TabPane-center'>
                        <div className='Molstar-div2'>{this.state.aciveKey == item.pdb && <WrappedIframe pdbLink={this.state.pdbLink} />}</div>
                        <div className='Structure-right'>
                          <Form layout='horizontal'>
                            <Form.Item label='详情' {...formItemLayout}>
                              <div>method: {getStructureList.method}</div>
                              <div>name: {getStructureList.name}</div>
                              <div>pdb_datatime: {getStructureList.pdb_datatime}</div>
                              <div>resolution: {getStructureList.resolution}</div>
                            </Form.Item>
                            <Form.Item label='References ' {...formItemLayout}>
                              {getStructureList.References &&
                                getStructureList.References.map((item, index) => {
                                  return (
                                    <Button
                                      type='primary'
                                      onClick={() => {
                                        this.getReferences(item);
                                      }}
                                      key={index}
                                      style={{ marginRight: '5px' }}
                                    >
                                      {item}
                                    </Button>
                                  );
                                })}
                            </Form.Item>
                          </Form>
                          <Collapse accordion>
                            <Panel header='对齐' key='1'>
                              <div className='form-div'>
                                <Form onSubmit={this.handleSubmit} className='login-form'>
                                  <Form.Item label='Ref.PDB' {...formItemLayout2}>
                                    <div>
                                      <Select style={{ width: '100px' }} value={this.state.superpositionData[0].pdbID} onChange={this.SelectValue}>
                                        {DetailsData.Structure.map((item, index) => {
                                          return (
                                            <Option key={index.pdb} value={item.pdb.toLowerCase()}>
                                              {item.pdb.toLowerCase()}
                                            </Option>
                                          );
                                        })}
                                      </Select>
                                      <Input
                                        placeholder='请输入Chain'
                                        onChange={this.getValue}
                                        value={this.state.superpositionData[0].chainID}
                                        style={{
                                          width: '100px',
                                        }}
                                      />
                                    </div>
                                  </Form.Item>
                                  {formItems}
                                  <Form.Item {...formItemLayoutWithOutLabel}>
                                    {sum < 2 && (
                                      <Button type='dashed' onClick={this.add} style={{ width: '60%' }}>
                                        <Icon type='plus' /> Add field
                                      </Button>
                                    )}
                                  </Form.Item>
                                  <Form.Item {...formItemLayoutWithOutLabel}>
                                    <Button type='primary' htmlType='submit'>
                                      对齐
                                    </Button>
                                  </Form.Item>
                                </Form>
                              </div>
                            </Panel>
                            <Panel header='抽取配体' key='2'>
                              <Form layout='horizontal'>
                                <Form.Item label='配体列表' {...formItemLayout}>
                                  {getStructureList.ligand_up_list &&
                                    getStructureList.ligand_up_list.map((item, index) => {
                                      return (
                                        <Popover
                                          content={
                                            <div>
                                              <div
                                                key={index}
                                                style={{
                                                  width: '100px',
                                                  wordWrap: 'break-word',
                                                  wordBreak: 'normal',
                                                }}
                                              >
                                                {item.comp_name}
                                              </div>

                                              <Jsme height='100px' width='100px' options='depict,useopenchemlib' smiles={item.smiles} />
                                            </div>
                                          }
                                        >
                                          {
                                            <Button type='primary' style={{ marginRight: '5px' }}>
                                              {item.name}
                                            </Button>
                                          }
                                        </Popover>
                                      );
                                    })}
                                </Form.Item>
                                <Form.Item label='配体选择' {...formItemLayout}>
                                  <Select style={{ width: 250 }} value={this.state.listData.ligand} size='large' onChange={this.LigandChange}>
                                    {getStructureList.ligand_list &&
                                      getStructureList.ligand_list.map((item, index) => {
                                        return (
                                          <Option key={index} value={item}>
                                            {item}
                                          </Option>
                                        );
                                      })}
                                  </Select>
                                </Form.Item>
                                <Form.Item label='搜索半径' {...formItemLayout}>
                                  <InputNumber
                                    style={{ width: 250 }}
                                    min={getStructureList.resolution}
                                    max={10}
                                    placeholder={'请输入大于resolutiond数字'}
                                    step={0.1}
                                    size='large'
                                    onChange={this.getResolutionData}
                                  />
                                </Form.Item>
                                <Form.Item label='Search' {...formItemLayout}>
                                  <Button
                                    type='primary'
                                    style={{ marginLeft: 50, width: 150 }}
                                    size='large'
                                    loading={this.state.loading}
                                    disabled={getStructureList.ligand_list.length === 0}
                                    onClick={this.getList}
                                  >
                                    Search
                                  </Button>
                                </Form.Item>
                              </Form>
                            </Panel>
                          </Collapse>
                        </div>
                      </div>
                      <Table bordered rowKey='item' dataSource={getStructureList.chain} pagination={false} columns={columnsChain} />
                    </TabPane>
                  );
                })}
              </Tabs>
            </Panel>
          </Collapse>
        </Spin>
      </div>
    );
  }
}
